research-article
Authors: Aditya Satishkumar Bantwal, Amit Kumar Bhayadia, Hui Meng
Volume 178, Issue C
Published: 19 September 2024 Publication History
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Abstract
Background
A promising approach to cuff-less, continuous blood pressure monitoring is to estimate blood pressure (BP) from Pulse Wave Velocity (PWV). However, most existing PWV-based methods rely on empirical BP-PWV relations and have large prediction errors, which may be caused by the implicit assumption of thin-walled, linear elastic arteries undergoing small deformations. Our objective is to understand the BP-PWV relationship in the absence of such limiting assumptions.
Method
We performed Fluid-Structure Interaction (FSI) simulations of the radial artery and the common carotid artery under physiological flow conditions. In these dynamic simulations, we employed two constitutive models for the arterial wall: the linear elastic model, implying a thin-walled linear elastic artery undergoing small deformations, and the Holzapfel-Gasser-Ogden (HGO) model, accounting for the nonlinear effects of collagen fibers and their orientations on the large arterial deformation.
Results
Despite the changing BP, the linear elastic model predicts a constant PWV throughout a cardiac cycle, which is not physiological. The HGO model correctly predicts a positive BP-PWV correlation by capturing the nonlinear deformation of the artery, showing up to 50% variations of PWV in a cardiac cycle.
Conclusion
Dynamic FSI simulations reveal that the BP-PWV relationship strongly depends on the arterial constitutive model, especially in the radial artery. To infer BP from PWV, one must account for the varying PWV, a consequence of the nonlinear arterial response due to collagen fibers. Future efforts should be directed towards robust measurement of time-varying PWV if it is to be used to predict BP.
Highlights
•
Existing, inaccurate PWV-based BP prediction models assume linear elastic artery.
•
Fluid-Structure Interaction (FSI) simulations reveal impact of constitutive model.
•
Linear elastic model incorrectly predicts a constant PWV in a cardiac cycle.
•
HGO model predicts a positive BP-PWV correlation, hence time-varying PWV.
•
Cuffless BP monitoring device should include varying PWV/nonlinear artery response.
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Index Terms
Critical role of arterial constitutive model in predicting blood pressure from pulse wave velocity
Applied computing
Life and medical sciences
Consumer health
Health care information systems
Health informatics
Physical sciences and engineering
Mathematics and statistics
Computing methodologies
Modeling and simulation
Model development and analysis
Mathematics of computing
Index terms have been assigned to the content through auto-classification.
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Published In
Computers in Biology and Medicine Volume 178, Issue C
Aug 2024
1533 pages
Issue’s Table of Contents
Elsevier Ltd.
Publisher
Pergamon Press, Inc.
United States
Publication History
Published: 19 September 2024
Author Tags
- Pulse wave velocity
- Fluid-structure interaction
- Radial artery
- Moens-Korteweg equation
- Non-invasive blood pressure monitoring
- Nonlinear constitutive model
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